The role of DPYD and the effects of DPYD suppressor luteolin combined with 5‐FU in pancreatic cancer

The role of DPYD and the effects of DPYD suppressor luteolin combined with 5‐FU in pancreatic cancer

Abstract Background Despite advances in the treatment of cancer, pancreatic ductal adenocarcinoma (PDAC) remains highly lethal due to the lack of effective therapies. Our previous study showed that Luteolin (Lut), a flavonoid, suppressed pancreatocarcinogenesis and reduced the expression of dihydrop...

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Main Authors: Hiroyuki Kato, Motonori Sato, Aya Naiki‐Ito, Shingo Inaguma, Makoto Sano, Masayuki Komura, Yuko Nagayasu, Kuang Xiaochen, Akihisa Kato, Yoichi Matsuo, Hideaki Ijichi, Satoru Takahashi
Format: Article
Language:English
Published: Wiley 2024-08-01
Series:Cancer Medicine
Subjects:
5‐fluorouracil
combination drug therapy
dihydropyrimidine dehydrogenase
luteolin
pancreatic cancer
Online Access:https://doi.org/10.1002/cam4.70124
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https://doi.org/10.1002/cam4.70124

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