Oncogenic mutant KRAS inhibition through oxidation at cysteine 118

Oncogenic mutant KRAS inhibition through oxidation at cysteine 118

Specific reactive oxygen species activate the GTPase Kirsten rat sarcoma virus (KRAS) by reacting with cysteine 118 (C118), leading to an electron transfer between C118 and nucleoside guanosine diphosphate (GDP), which causes the release of GDP. Here, we have mimicked permanent oxidation of human KR...

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Main Authors: Maximilian Kramer‐Drauberg, Ettore Petrini, Alessia Mira, Enrico Patrucco, Rossella Scardaci, Ilenia Savinelli, Haiyun Wang, Keying Qiao, Giovanna Carrà, Marie‐Julie Nokin, Zhiwei Zhou, Kenneth D. Westover, David Santamaria, Paolo E. Porporato, Chiara Ambrogio
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Molecular Oncology
Subjects:
cysteine modification
KRAS C118
NSCLC
oncogene
redox regulation
ROS
Online Access:https://doi.org/10.1002/1878-0261.13798
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https://doi.org/10.1002/1878-0261.13798

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