Analytical Solutions of PBTK Models for Evaluating the Impact of Surface Diffusion Characteristics on the Leaching Profile of Implant Byproducts

Toxicokinetic or pharmacokinetic models, physiologically based or not, offer a unique avenue to understand the transport of toxins or pharmaceuticals in living organisms. The availability of analytical solutions to such models offers the means to engage in a plethora of applications. In the present...

Full description

Saved in:

Bibliographic Details
Main Authors:	Matheos Giakoumi, Konstantinos Kapnisis, Andreas Anayiotos, Pavlos S. Stephanou
Format:	Article
Language:	English
Published:	MDPI AG 2024-11-01
Series:	Mathematical and Computational Applications
Subjects:	medical implants physiologically based toxicokinetic (PBTK) models modeling and simulations (M&S) absorption, distribution, metabolism, and excretion (ADME) analytical solutions matrix exponential
Online Access:	https://www.mdpi.com/2297-8747/29/6/101
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Deriving a Health-Based Guidance Value for 9,10-Anthraquinone via integrating PBTK modeling-based reverse dosimetry and In Vitro bioassays
by: Da Zhang, et al.
Published: (2025-07-01)

Advancing understanding of human variability through toxicokinetic modeling, in vitro-in vivo extrapolation, and new approach methodologies
by: Anna Kreutz, et al.
Published: (2024-11-01)

A Systematic Review of the Toxicokinetics of Micro- and Nanoplastics in Mammals Following Digestive Exposure
by: Raluca Paula Popa, et al.
Published: (2025-05-01)

stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments
by: Roberto Visintainer, et al.
Published: (2025-01-01)

Elucidating impacts of partitioning and transmembrane permeability on absorption of chemicals in human gastrointestinal tract
by: Shenghong Wang, et al.
Published: (2024-11-01)

Safety Profile, Toxicokinetic, and Intestinal Absorption Differences of a Naturally-Derived Anti-Rheumatic Drug, Sinomenine Hydrochloride, in Normal and Arthritic Rats
by: Yini He, et al.
Published: (2025-04-01)

Assessing the Application of Physiologically Based Pharmacokinetic Models in Acute Chemical Incidents
by: Sydney Boone, et al.
Published: (2025-03-01)

Binding of per- and polyfluoroalkyl substances with liver and serum proteins in rats: implications for physiologically based pharmacokinetic modelling
by: Xiarui Fan, et al.
Published: (2025-07-01)

Study of the Safety and Toxicokinetic Parameters of the Drug Eladis® in Preclinical Trials with Repeated Administration
by: A. A. Matichin, et al.
Published: (2025-04-01)

The investigation of toxicokinetics parameters of cyanide and thiocyanate in mice
by: Sadettin Tanyıldızı, et al.

An Analytic Solution for Riccati Matrix Delay Differential Equation using Coupled Homotopy-Adomian Approach
by: Khalid Hammood AL-Jizani, et al.
Published: (2022-08-01)

The investigation of sodium thiosulfate effects on the toxicokinetics of cyanide and thiocyanate
by: İbrahim Pirinçci, et al.

PFOA, PFOS and PFHxS toxicokinetic considerations for the development of an in vivo approach for assessing PFAS relative bioavailability in soil
by: Albert L. Juhasz, et al.
Published: (2025-01-01)

The AI Act from the Perspective of Administrative Law: Much Ado About Nothing?
by: Oriol Mir, et al.
Published: (2025-03-01)

Potential systemic availability classification of chemicals for safety assessment
by: René Geci, et al.
Published: (2025-08-01)

Oral Exposure to <i>Chlorella sorokiniana</i> Detoxifies Deoxynivalenol, Ochratoxin A, and Fumonisin B1 In Vitro and In Vivo
by: Hiroki Yamaguchi, et al.
Published: (2025-06-01)

Comparative Toxicokinetics and Biomarker Responses of Typical Psychiatric Pharmaceuticals in <i>Daphnia magna</i>
by: Haohan Yang, et al.
Published: (2025-06-01)

Hepatotoxicity Induced by Methyl Eugenol: Insights from Toxicokinetics, Metabolomics, and Gut Microbiota
by: Liang Chen, et al.
Published: (2024-10-01)

Uptake, Elimination and Metabolism of Brominated Dibenzofurans in Mice
by: Nguyen Minh Tue, et al.
Published: (2024-09-01)

INVESTIGATION OF BIOKINETIC PECULIARITIES OF STRONTIUM-90 METABOLISM MODEL AND POSSIBILITY OF AN ESTIMATION OF RADIONUCLIDE INTAKE LEVEL BASING ON THE RESULTS OF THE MEASUREMENTS OF ACTIVITY IN URINE
by: V. S. Repin
Published: (2015-08-01)

Ingesting chitosan can promote excretion of microplastics
by: Di Liu, et al.
Published: (2025-04-01)

Interaction of Glucose with ZnO Nanoparticles
by: P.K. Samanta, et al.
Published: (2014-06-01)

Model of Urine Accumulation in the Bladder and Method for Predicting Unconstrained Urine Volume Based on Absorption Spectrum of Urine
by: Y. Kurihara, et al.
Published: (2020-01-01)

Microplastic size matters for absorption and excretion by Artemia salina and Acipenser ruthenus larvae in models of water pollution and food chain transfer
by: Yulia A. Frank, et al.
Published: (2024-08-01)

Antimalarial activity of caged xanthone isolated compounds from Cratoxylum sumatranum stem bark: In vitro and in silico approaches
by: Firman; Wardana Wicaksana
Published: (2024-10-01)

Synthesis, ADME, and In Silico Molecular Docking Study of Novel N-Substituted <i>β</i>-Carboline Analogs as a Potential Anticancer Agent
by: Sunil Gaikwad
Published: (2024-11-01)

Preclinical Evaluation of the Oral Toxicity, Genotoxicity, and Safety Pharmacology of LPM4870108, a Novel Potent Tropomyosin Receptor Kinase Inhibitor
by: Xiaochen Zhang, et al.
Published: (2025-08-01)

Developing a predictive model for blood-brain-barrier permeability to explore relevance of in vitro neurotoxicity data for in vivo risk assessment
by: Siena E. Illa, et al.
Published: (2025-04-01)

Bioaccumulation, Ecotoxicity, and Microbial Responses in <i>Hoplobatrachus rugulosus</i> Tadpoles Following Co-Exposure to Imidacloprid and Microplastics
by: Xinyu Hu, et al.
Published: (2025-06-01)

Effect of Microplastics on the Bioavailability of (Semi-)Metals in the Soil Earthworm <i>Eisenia fetida</i>
by: Xue Xiao, et al.
Published: (2025-04-01)

In silico study of properties in the series of 1-alkyl-4-(((5-nitrofuran-2-yl)methylene)amino)- 1,2,4-triazole halides
by: L. I. Kucherenko, et al.
Published: (2024-02-01)

Structural activity of synthesized pyrimidine-thiophene and pyrimidine-thiadiazole conjugates as anticancer agents
by: Abeer Mogadem, et al.
Published: (2024-10-01)

Effect of aminophylline on the pharmacokinetics of amikacin in Sprague-Dawley rats
by: Seth Kwabena Amponsah, et al.
Published: (2019-03-01)

Cerium oxide nanoparticles, physical and chemical properties, applications and toxicological implications: A review
by: Mohammad Mohajeri, et al.
Published: (2025-05-01)

Toxicokinetics of a Single Oral Dose of Aflatoxin B<sub>1</sub> in Plasma, Feces, and Urine of Male Donkeys
by: Yulong Feng, et al.
Published: (2025-04-01)

Comparative temporal response of toxicity for the neonicotinoid clothianidin and organophosphate dimethoate insecticides in two species of solitary bee (Osmia bicornis and Osmia cornuta)
by: Helen Hesketh, et al.
Published: (2025-02-01)

Thallium Poisoning: Case Report and Scoping Review on Diagnostic Delay and Therapeutic Outcome
by: Paolo Maurizio Soave, et al.
Published: (2025-02-01)

Insufficiencies of the Single Exponential Model and Efficiency of the Double Exponential Model in the Optimization of Solar Cells Efficiency
by: A. Zerga, et al.
Published: (1998-01-01)

PENERAPAN MODEL EKSPONENSIAL DAN MODEL LOGISTIK UNTUK MEMPROYEKSIKAN JUMLAH PENDUDUK KABUPATEN LOMBOK TIMUR
by: Jihan Khairunnisa
Published: (2025-04-01)

In Silico Evaluation of the Biopharmaceutical and Pharmacokinetic Behavior of Metronidazole from Coated Colonic Release Matrix Tablets
by: Roberto Arévalo-Pérez, et al.
Published: (2025-05-01)