Analytical Solutions of PBTK Models for Evaluating the Impact of Surface Diffusion Characteristics on the Leaching Profile of Implant Byproducts

Analytical Solutions of PBTK Models for Evaluating the Impact of Surface Diffusion Characteristics on the Leaching Profile of Implant Byproducts

Toxicokinetic or pharmacokinetic models, physiologically based or not, offer a unique avenue to understand the transport of toxins or pharmaceuticals in living organisms. The availability of analytical solutions to such models offers the means to engage in a plethora of applications. In the present...

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Bibliographic Details
Main Authors: Matheos Giakoumi, Konstantinos Kapnisis, Andreas Anayiotos, Pavlos S. Stephanou
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Mathematical and Computational Applications
Subjects:
medical implants
physiologically based toxicokinetic (PBTK) models
modeling and simulations (M&S)
absorption, distribution, metabolism, and excretion (ADME)
analytical solutions
matrix exponential
Online Access:https://www.mdpi.com/2297-8747/29/6/101
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