Integrative Multiomics Profiling of Mouse Hippocampus Reveals Transcriptional Upregulation of Interferon‐Stimulated Genes Through PU.1 Regulator in Microglial Activation Induced by Chronic Cerebral Hypoperfusion

Integrative Multiomics Profiling of Mouse Hippocampus Reveals Transcriptional Upregulation of Interferon‐Stimulated Genes Through PU.1 Regulator in Microglial Activation Induced by Chronic Cerebral Hypoperfusion

ABSTRACT Chronic cerebral hypoperfusion (CCH) is a significant factor that accelerates cognitive deterioration, yet the mechanisms of hippocampal microglial activation in this context remain unclear. Using an integrative multiomics approach, we investigated the transcriptional and epigenomic landsca...

Full description

Saved in:

Bibliographic Details
Main Authors:	Zengyu Zhang, Dewen Ru, Zhuohang Liu, Zimin Guo, Lei Zhu, Yuan Zhang, Min Chu, Yong Wang, Jing Zhao
Format:	Article
Language:	English
Published:	Wiley 2025-05-01
Series:	MedComm
Subjects:	chronic cerebral hypoperfusion (CCH) interferon signaling microglial activation multiomics analysis PU.1
Online Access:	https://doi.org/10.1002/mco2.70157
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Downregulation of Notch Signaling‐Stimulated Genes in Neurovascular Unit Alterations Induced by Chronic Cerebral Hypoperfusion
by: Dewen Ru, et al.
Published: (2024-11-01)

Association analysis of an anti-obesity mechanism and key ripened Pu-erh tea bioactive components by mimicking human general tea drinking
by: Junyu Liu, et al.
Published: (2025-02-01)

Structure stability of (U, Pu) C and (U, Pu) N compositions
by: William A. Watson, et al.
Published: (2025-06-01)

Histological changes in the hippocampus of both cerebral hemispheres of Wistar and SHR rats under experimental chronic cerebral hypoperfusion
by: O. Yu. Harmatina, et al.
Published: (2020-12-01)

Integrated analysis of chromatin and transcriptomic profiling of the striatum after cerebral hypoperfusion in mice
by: Shijia Le, et al.
Published: (2025-01-01)

INTERSECTİONAL (α,A)-SOFT NEW-İDEALS İN PU-ALGEBRAS
by: Samy Mohammed Mostafa, et al.
Published: (2016-09-01)

Regional cerebral hypoperfusion as a cause of symptoms and progression of multiple sclerosis
by: L. N. Prakhova, et al.
Published: (2020-01-01)

EmptyDropsMultiome discriminates real cells from background in single-cell multiomics assays
by: Stathis Megas, et al.
Published: (2024-05-01)

USP22 inhibits microglial M1 polarization by regulating the PU.1/NLRP3 inflammasome pathway
by: Ming-chen Yu, et al.
Published: (2025-01-01)

Moyamoya disease: A human model for chronic hypoperfusion and intervention in Alzheimer's disease
by: Xiang Zou, et al.
Published: (2022-01-01)

Pulsed radiofrequency alleviates neuropathic pain by upregulating MG53 to inhibit microglial activation
by: Yuanxin Huang, et al.
Published: (2024-12-01)

Influence of physical loading on behavioral reactions of rats in cerebral hypoperfusion
by: V. V. Сhrishtop, et al.
Published: (2022-10-01)

Upregulation of VEGFA through the adenosine A2A receptor is a crucial pathway for inhibiting pericyte apoptosis in chronic cerebral hypoperfusion
by: Deyue Li, et al.
Published: (2025-07-01)

Progress on Pu-238 production at Idaho National Laboratory from February 2022 to July 2023 [version 1; peer review: 2 approved, 3 approved with reservations]
by: Erik Rosvall, et al.
Published: (2024-09-01)

Selective vulnerability of medial temporal regions to short-term blood pressure variability and cerebral hypoperfusion in older adults
by: Isabel J. Sible, et al.
Published: (2022-03-01)

Focusing on perihematomal hypoperfusion following intracerebral hemorrhage: from oxidative stress to prospective therapeutic approaches
by: Huang Zhipeng, et al.
Published: (2025-08-01)

Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis
by: Weiping Xiao, et al.
Published: (2025-06-01)

PU.1 upregulation is linked to improved prognosis in non-small cell lung cancer
by: Katja Hohenberger, et al.
Published: (2025-08-01)

The expression and association of MATK in chronic hypoperfusion patients with white matter hyperintensity
by: Ming Zhao, et al.
Published: (2025-08-01)

Collagenase Clostridium Histolyticum Versus Percutaneous Needle Fasciotomy for Dupuytren’s Disease: A Systematic Review and Meta-Analysis
by: Ishith Seth, et al.
Published: (2025-02-01)

Multiomics Assessment of the Gut Microbiome in Rare Hyperoxaluric Conditions
by: Nadim Zaidan, et al.
Published: (2024-06-01)

Detection of composition of functional component theabrownins in Pu-erh tea by degradation method
by: Simin Hu, et al.
Published: (2022-05-01)

Immunohistochemical analysis of microglial changes in the experimental acute hepatic encephalopathy
by: T. V. Shulyatnikova
Published: (2021-05-01)

PU.1 dictates β-amyloid-induced TREM2 expression upregulation in microglia in a transgenic model of Alzheimer’s disease
by: Zhen Wei, et al.
Published: (2025-05-01)

The multiomics landscape of plasma exosomes in first-episode drug-naïve of schizophrenia
by: Yeqing Dong, et al.
Published: (2025-08-01)

Network-based analyses of multiomics data in biomedicine
by: Rachit Kumar, et al.
Published: (2025-05-01)

Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals
by: Yi Wu, et al.
Published: (2025-07-01)

Effect of microbe and irradiation on quality transformation of raw Pu’er tea during storage
by: TIAN Xuefeng, et al.
Published: (2021-06-01)

Optimal Neutron Spectrum Database for In‐reactor 238Pu Production
by: Qingquan Pan, et al.
Published: (2025-03-01)

Histone deacetylases: the critical enzymes for microglial activation involved in neuropathic pain
by: Yi Ding
Published: (2025-03-01)

Artificial Heart Valve Scaffold Based on Electrospun PCL/PU Three-Layer Composite Fibers
by: Xu Gao, et al.
Published: (2024-12-01)

Effect of Graphene Content on Structure and Glossiness of PU/CuCoating Sprayed on Photovoltaic Panel Surface
by: JIN Hui-ling, DING Lan-hua, CHEN Ji-hong
Published: (2021-08-01)

The role of multiomics in revealing the mechanism of skin repair and regeneration
by: Shaoyan Shi, et al.
Published: (2025-01-01)

Protective effect of Pu-erh tea polysaccharides and catechins compound on immunosuppressive mice
by: CHU Xi, ZHOU Yufei, LIU Ailing, ZHOU Miao, LI Dongfang, ZHANG Sheng
Published: (2025-06-01)

Hypoperfusion Intensity Ratio as an Indirect Imaging Surrogate in Patients With Anterior Circulation Large‐Vessel Occlusion and Association of Baseline Characteristics With Poor Collateral Status
by: Omar Hamam, et al.
Published: (2024-08-01)

Identification of candidate proteins influencing spermatogenesis in Shandong black cattle via integrated multiomics analysis
by: Qiuyue Zhao, et al.
Published: (2025-07-01)

Dolutegravir Derivatives Alleviate LPS-Induced Microglial Inflammation by Suppressing STAT1/3 Nuclear Translocation
by: Wang L, et al.
Published: (2025-05-01)

Protective Effects of N-Acetylcysteine in Alleviating Cocaine-Mediated Microglial Activation and Neuroinflammation
by: Uma Maheswari Deshetty, et al.
Published: (2025-07-01)

MULTIOMICS INTEGRATION IN ANTI-TUBERCULOSIS DRUG DISCOVERY
by: Yaro Abubakar
Published: (2025-05-01)

Flavor Quality and Lipid-Lowering Function of Mixed Fermented Pu-erh Tea with Various Monascus Species
by: Xiaomin Chen, et al.
Published: (2025-05-01)