Integrative Multiomics Profiling of Mouse Hippocampus Reveals Transcriptional Upregulation of Interferon‐Stimulated Genes Through PU.1 Regulator in Microglial Activation Induced by Chronic Cerebral Hypoperfusion

Integrative Multiomics Profiling of Mouse Hippocampus Reveals Transcriptional Upregulation of Interferon‐Stimulated Genes Through PU.1 Regulator in Microglial Activation Induced by Chronic Cerebral Hypoperfusion

ABSTRACT Chronic cerebral hypoperfusion (CCH) is a significant factor that accelerates cognitive deterioration, yet the mechanisms of hippocampal microglial activation in this context remain unclear. Using an integrative multiomics approach, we investigated the transcriptional and epigenomic landsca...

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Bibliographic Details
Main Authors: Zengyu Zhang, Dewen Ru, Zhuohang Liu, Zimin Guo, Lei Zhu, Yuan Zhang, Min Chu, Yong Wang, Jing Zhao
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:MedComm
Subjects:
chronic cerebral hypoperfusion (CCH)
interferon signaling
microglial activation
multiomics analysis
PU.1
Online Access:https://doi.org/10.1002/mco2.70157
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https://doi.org/10.1002/mco2.70157

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