Self-degradable “gemini-like” ionizable lipid-mediated delivery of siRNA for subcellular-specific gene therapy of hepatic diseases

Self-degradable “gemini-like” ionizable lipid-mediated delivery of siRNA for subcellular-specific gene therapy of hepatic diseases

Tailored lipid nanoparticles (LNPs)-mediated small interfering RNA (siRNA) nanomedicines show promise in treating liver disease, such as acute liver injury (ALI) and non-alcoholic steatohepatitis (NASH). However, constructing LNPs that address biosafety concerns, ensure efficient delivery, and targe...

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Bibliographic Details
Main Authors: Qiu Wang, Bin Wan, Yao Feng, Zimeng Yang, Dan Li, Fan Liu, Ya Gao, Chang Li, Yanhua Liu, Yongbing Sun, Zhonggui He, Cong Luo, Jin Sun, Qikun Jiang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Self-degradable “gemini-like” ionizable lipids
Lipid nanoparticles
siRNA delivery
Gene therapy
Liver macrophages targeting
Hepatic diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525002242
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http://www.sciencedirect.com/science/article/pii/S2211383525002242

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