Optimization of Solid Lipid Nanoparticle Formulation Using Design of Experiments, PART I: <i>Strategic Tool for the Determination of Critical Parameters Regarding Formulation and Process</i>

Optimization of Solid Lipid Nanoparticle Formulation Using Design of Experiments, PART I: <i>Strategic Tool for the Determination of Critical Parameters Regarding Formulation and Process</i>

This study presents a methodological framework for optimizing “blank” solid lipid nanoparticles (SLNs), focusing on the use of a design of experiments (DOE) approach. Rather than emphasizing the applications of SLNs, the objective is to identify and optimize critical formulation and process paramete...

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Bibliographic Details
Main Authors: Margot Cassayre, Dany Teles de Souza, Magalie Claeys-Bruno, Alexandre Altié, Philippe Piccerelle, Christophe Sauzet
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Nanomaterials
Subjects:
solid lipid nanoparticle (SLN)
optimization
formulation
physical characterization
design of experiments (DOE)
statistics
Online Access:https://www.mdpi.com/2079-4991/15/13/1034
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