Fabrication of a novel 3D-printed perfusion bioreactor for complex cell culture models

Abstract We introduce a novel fabrication method for developing a 3D-printed perfusion bioreactor (3D-PBR) to facilitate the in situ growth and differentiation of human bone marrow (BM)-derived mesenchymal stem cells (MSCs) while enabling coculture with vascular cells. To recapitulate human physiolo...

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Bibliographic Details
Main Authors: Brian H. Jun, Jacob E. Torrez, David J. Ross, Brian M. Patterson, Mohammad O. Ishak, Arasely M. Rodriguez, Jennifer F. Harris, Katie L. Davis-Anderson
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-94093-z
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