Serine-129 phosphorylated α-synuclein drives mitochondrial dysfunction and calcium dysregulation in Parkinson’s disease model
Phosphorylation of α-synuclein at serine-129 (p-α-syn) is a hallmark of Parkinson’s disease (PD) and constitutes nearly 90% of α-synuclein in Lewy bodies, playing a critical role in disease progression. Despite its pathological significance, the molecular targets and mechanisms driving p-α-syn-induc...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1538166/full |
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