Transcriptomic profiling of skeletal muscle in the DMD mdx rat model of Duchenne muscular dystrophy

Transcriptomic profiling of skeletal muscle in the DMD mdx rat model of Duchenne muscular dystrophy

Abstract Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disorder caused by a mutation in the Dmd gene, leading to progressive muscle degradation, increasing weakness, and typically resulting in death before the third decade of life. To investigate the pathobiology of DMD, this stud...

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Main Authors: Abdolvahab Ebrahimpour Gorji, Katarzyna Kliczkowska, Marcin Ollik, Caroline Le Guiner, Jacek Wilczak, Wojciech Bielecki, Piotr Ostaszewski, Masoud Shirali, Zahra Roudbari, Tomasz Sadkowski
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Duchenne muscular dystrophy (DMD)
Dystrophin gene mutation
Skeletal muscle degeneration
RNA-seq gene expression analysis
MAPK signaling pathway, DMD mdx rat model
Online Access:https://doi.org/10.1038/s41598-025-14756-9
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https://doi.org/10.1038/s41598-025-14756-9

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