Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol.

Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol.

Genome-wide association studies (GWAS) have successfully identified loci associated with quantitative traits, such as blood lipids. Deep resequencing studies are being utilized to catalogue the allelic spectrum at GWAS loci. The goal of these studies is to identify causative variants and missing her...

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Main Authors: Sumeet A Khetarpal, Andrew C Edmondson, Avanthi Raghavan, Hemanth Neeli, Weijun Jin, Karen O Badellino, Serkalem Demissie, Alisa K Manning, Stephanie L DerOhannessian, Megan L Wolfe, L Adrienne Cupples, Mingyao Li, Sekar Kathiresan, Daniel J Rader
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-12-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002393&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002393&type=printable

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