Activation of Nuclear Receptor CAR: A Pathway to Delay Aging through Enhanced Capacity for Xenobiotic Resistance

Activation of Nuclear Receptor CAR: A Pathway to Delay Aging through Enhanced Capacity for Xenobiotic Resistance

Abstract Environmental factors are linked to aging and age‐related diseases. Emerging evidence suggests that enhancing body's resistance to xenobiotics might be an anti‐aging strategy. The constitutive androstane receptor (CAR) regulates drug‐metabolizing enzymes and transporters, coordinating...

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Main Authors: Jing Yu, Xiaoyan Gao, Hang Shi, Lijun Zhang, Wenlong Nie, Ruochen Zhang, Minglv Fang, Ying Liu, Yingxuan Yan, Bingbing Fan, Chengyuan Wu, Cheng Huang, Shengjie Fan
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
anti‐aging
age‐related neurodegeneration
constitutive androstane receptor (CAR)
environmental stimulus
xenobiotic resistance
Online Access:https://doi.org/10.1002/advs.202416823
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https://doi.org/10.1002/advs.202416823

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