Evolutionarily conserved amino acids in MHC-II mediate bat influenza A virus entry into human cells.

Evolutionarily conserved amino acids in MHC-II mediate bat influenza A virus entry into human cells.

The viral hemagglutinins of conventional influenza A viruses (IAVs) bind to sialylated glycans on host cell surfaces for attachment and subsequent infection. In contrast, hemagglutinins of bat-derived IAVs target major histocompatibility complex class II (MHC-II) for cell entry. MHC-II proteins from...

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Main Authors: Okikiola M Olajide, Maria Kaukab Osman, Jonathan Robert, Susanne Kessler, Lina Kathrin Toews, Thiprampai Thamamongood, Jacques Neefjes, Antoni G Wrobel, Martin Schwemmle, Kevin Ciminski, Peter Reuther
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-07-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002182&type=printable
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002182&type=printable

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