Sulfhydrated albumin transmits H2S signaling and ameliorates DOX-induced multiorgan injuries

Sulfhydrated albumin transmits H2S signaling and ameliorates DOX-induced multiorgan injuries

Hydrogen sulfide (H2S) is a vital signaling molecule involved in various physiological processes; however, the mechanisms underlying its systemic signaling remain poorly understood. We hypothesized that albumin, the predominant plasma protein and a vital sulfhydryl carrier, mediated systemic H2S sig...

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Bibliographic Details
Main Authors: Yijun Xu, Yang Sui, Rui Jiang, Xin Wang, Mika Suda, Manabu Niimi, Zhimin Mao, Zhen Zhang, Shao-Ling Zhang, Jianglin Fan, Jian Yao
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Redox Biology
Subjects:
Protein sulfhydration
Sulfhydrated albumin
H2S
cAMP signaling pathway
Inflammatory responses
Doxorubicin toxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001442
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http://www.sciencedirect.com/science/article/pii/S2213231725001442

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