Affibodies as valuable tool to prevent β2m aggregation under lysosomal-like conditions

Affibodies as valuable tool to prevent β2m aggregation under lysosomal-like conditions

Abstract Beta-2 microglobulin (β2m) is a small protein that forms the invariant subunit of the Major Histocompatibility Complex I. Monomeric β2m is stable under physiological conditions, however high local concentrations can induce misfolding, leading to amyloid deposition. This accumulation has bee...

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Bibliographic Details
Main Authors: Cristina Visentin, Giulia Rizzi, Wen Yin, Mathilde Hotot, Dipambita Roy, Torbjörn Gräslund, Riccardo Capelli, Stefano Ricagno
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Biology Direct
Subjects:
Amyloid aggregation
Multiple myeloma
Affibodies
Beta-2 microglobulin
Affinity molecules
Online Access:https://doi.org/10.1186/s13062-025-00659-2
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https://doi.org/10.1186/s13062-025-00659-2

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