CXCR1/2 antagonism inhibits neutrophil function and not recruitment in cancer

CXCR1/2 antagonism inhibits neutrophil function and not recruitment in cancer

The level of tumor and circulating CXCR1/2-expressing neutrophils and CXCR1/2 ligands correlate with poor patient outcomes, inversely correlate with tumoral lymphocyte content, and predict immune checkpoint inhibitor (ICI) treatment failure. Accordingly, CXCR2-selective and CXCR1/2 dual inhibitors e...

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Bibliographic Details
Main Authors: Jeff W. Kwak, Helena Q. Nguyen, Alex Camai, Grace M. Huffman, Surapat Mekvanich, Naia N. Kenney, Xiaodong Zhu, Timothy W. Randolph, A. McGarry Houghton
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
Tumor microenvironment
neutrophils
lung cancer
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2384674
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https://www.tandfonline.com/doi/10.1080/2162402X.2024.2384674

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