Chronic sleep deprivation is associated with delayed puberty onset in rats, activation of proinflammatory cytokines and gut dysbiosis

Chronic sleep deprivation is associated with delayed puberty onset in rats, activation of proinflammatory cytokines and gut dysbiosis

Chronic sleep deprivation (CSD) in adolescents has become a trend with adverse health outcomes. Previous studies have demonstrated that sleep deprivation causes inflammation, alters puberty onset, and changes the gut microbiome composition; however, the relationship between these is still unknown. T...

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Bibliographic Details
Main Authors: Shirley Priscilla Gunawan, Shih-Yi Huang, Jhih-Wei Hsu, Chia-Yuan Lin, Nam Nhat Nguyen, Te-Hsuan Tung, Shu-Ling Liang, Gilbert Aaron Lee, Chien-Tien Su, Yang Ching Chen
Format: Article
Language:English
Published: PeerJ Inc. 2025-07-01
Series:PeerJ
Subjects:
Rodent model
Chronic sleep deprivation
Proinflammatory cytokines
Puberty onset
Gut microbiome
Online Access:https://peerj.com/articles/19668.pdf
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