A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial Virus.

A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial Virus.

Recombinant subunit vaccines should contain minimal non-pathogen motifs to reduce potential off-target reactivity. We recently developed a vaccine antigen against respiratory syncytial virus (RSV), which comprised the fusion (F) glycoprotein stabilized in its pre-fusion trimeric conformation by &quo...

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Main Authors: Guillaume B E Stewart-Jones, Paul V Thomas, Man Chen, Aliaksandr Druz, M Gordon Joyce, Wing-Pui Kong, Mallika Sastry, Cinque Soto, Yongping Yang, Baoshan Zhang, Lei Chen, Gwo-Yu Chuang, Ivelin S Georgiev, Jason S McLellan, Sanjay Srivatsan, Tongqing Zhou, Ulrich Baxa, John R Mascola, Barney S Graham, Peter D Kwong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0128779
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https://doi.org/10.1371/journal.pone.0128779

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