A subset of circulating blood mycobacteria-specific CD4 T cells can predict the time to Mycobacterium tuberculosis sputum culture conversion.

A subset of circulating blood mycobacteria-specific CD4 T cells can predict the time to Mycobacterium tuberculosis sputum culture conversion.

We investigated 18 HIV-negative patients with MDR-TB for M. tuberculosis (Mtb)- and PPD-specific CD4 T cell responses and followed them over 6 months of drug therapy. Twelve of these patients were sputum culture (SC) positive and six patients were SC negative upon enrollment. Our aim was to identify...

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Main Authors: Catherine Riou, Clive M Gray, Masixole Lugongolo, Thabisile Gwala, Agano Kiravu, Pamela Deniso, Lynsey Stewart-Isherwood, Shaheed Vally Omar, Martin P Grobusch, Gerrit Coetzee, Francesca Conradie, Nazir Ismail, Gilla Kaplan, Dorothy Fallows
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0102178
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https://doi.org/10.1371/journal.pone.0102178

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