Novel bispecific antibody-drug conjugate targeting PD-L1 and B7-H3 enhances antitumor efficacy and promotes immune-mediated antitumor responses

Novel bispecific antibody-drug conjugate targeting PD-L1 and B7-H3 enhances antitumor efficacy and promotes immune-mediated antitumor responses

Background Antibody-drug conjugates (ADCs) offer a promising approach, combining monoclonal antibodies with chemotherapeutic drugs to target cancer cells effectively while minimizing toxicity.Methods This study examined the therapeutic efficacy and potential mechanisms of a bispecific ADC (BsADC) in...

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Bibliographic Details
Main Authors: Hui Yang, Xiaoting Chen, Zeng Wang, Zongliang Zhang, Meijun Zheng, Aiping Tong, Yijun Dong, Siyuan Luan, Yongdong Chen
Format: Article
Language:English
Published: BMJ Publishing Group 2024-10-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/10/e009710.full
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https://jitc.bmj.com/content/12/10/e009710.full

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