New structural scaffolds to enhance the metabolic stability of arginine-derived PAD4 inhibitors

New structural scaffolds to enhance the metabolic stability of arginine-derived PAD4 inhibitors

Although arginine-derived PAD inhibitors represented by Cl-amidine (2) showed strong inhibition of PAD4 enzymes and exhibited efficacies in a variety of cellular assays and animal studies, their metabolic instability is a significant challenge for pre-clinical and clinical research. On the basis of...

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Bibliographic Details
Main Authors: Yijiang Jia, Sina Bahraminejad, Chenyao Jiang, Ayijiang Taledaohan, Dejian Ma, Jianxiong Jiang, Yuji Wang, Jiawang Liu
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Results in Chemistry
Subjects:
Peptidyl arginine deiminase 4 (PAD4) inhibitor
Citrullination
Metabolic stability
BB-cl-amidine
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715625001456
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