Placental and cerebral circulation in fetuses of mothers with polycystic ovary syndrome and the effect of Metformin exposure

Placental and cerebral circulation in fetuses of mothers with polycystic ovary syndrome and the effect of Metformin exposure

Abstract Background Women with polycystic ovary syndrome (PCOS) have an increased risk of pregnancy complications and fetal growth restriction is reported. Increased head size has been reported in PCOS-offspring exposed to intrauterine metformin. We aimed to explore whether maternal PCOS-status, and...

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Main Authors: Emma Nordtvedt, Jörg Kessler, Cathrine Ebbing, Ganesh Acharya, Tone S. Løvvik, Kjell Å. Salvesen, Øyvind Salvesen, Eszter Vanky, Birgitte H. Kahrs
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Pregnancy and Childbirth
Subjects:
Polycystic ovary syndrome
Metformin
Cerebral blood flow
Fetal doppler measurements
Umbilical artery
Cerebroplacental ratio
Online Access:https://doi.org/10.1186/s12884-025-07866-9
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https://doi.org/10.1186/s12884-025-07866-9

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