Divergent neurodegeneration associations with choroid plexus volume and degree of calcification in cognitively normal APOE ε4 carriers and non-carriers

Divergent neurodegeneration associations with choroid plexus volume and degree of calcification in cognitively normal APOE ε4 carriers and non-carriers

Abstract Choroid plexus (CP), best known for producing CSF, also regulate inflammation and clear metabolic waste to maintain brain homeostasis. CP dysfunction is implicated in Alzheimer’s Disease (AD), with MRI studies showing CP enlargement in AD. The basis for CP enlargement is unknown. We hypothe...

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Main Authors: Ilker Ozsahin, Xiuyuan Wang, Liangdong Zhou, Ke Xi, Seyed Hani Hojjati, Emily Tanzi, Thomas Maloney, Edward K. Fung, Jonathan P. Dyke, Kewei Chen, Silky Pahlajani, Laura Beth McIntire, Ana Paula Costa, William Jones Dartora, Qolamreza R. Razlighi, Lidia Glodzik, Yi Li, Gloria C. Chiang, Henry Rusinek, Mony J. de Leon, Tracy A. Butler
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Choroid plexus
Calcification
Neurodegeneration
APOE
PiB PET
Online Access:https://doi.org/10.1038/s41598-025-97409-1
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https://doi.org/10.1038/s41598-025-97409-1

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