MEK inhibition prevents human skin graft rejection by promoting CD8+TCF1+ over CD8 effector T cells

MEK inhibition prevents human skin graft rejection by promoting CD8+TCF1+ over CD8 effector T cells

Summary: Pharmacological MEK inhibition might be an innovative approach to complete the immunosuppressive regimen that enables solid organ transplantation. While MEK inhibitors like trametinib are approved in oncology, their immunomodulatory properties remain poorly investigated in the context of or...

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Main Authors: Christine Chauveau, Veronique Nerriere-Daguin, Maeva Fourny, Cynthia Fourgeux, Thibaut Larcher, Laurence Delbos, Martin Braud, Lucas Brusselle, Olivia Rousseau, Jeremie Poschmann, Julien Verdier, Fabienne Haspot, Gilles Blancho, Simon Ville
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:iScience
Subjects:
Cell biology
Immune response
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225015718
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http://www.sciencedirect.com/science/article/pii/S2589004225015718

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