Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike.

Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike.

The spike (S) protein of SARS-CoV-2 has been observed in three distinct pre-fusion conformations: locked, closed and open. Of these, the function of the locked conformation remains poorly understood. Here we engineered a SARS-CoV-2 S protein construct "S-R/x3" to arrest SARS-CoV-2 spikes i...

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Main Authors: Kun Qu, Qiuluan Chen, Katarzyna A Ciazynska, Banghui Liu, Xixi Zhang, Jingjing Wang, Yujie He, Jiali Guan, Jun He, Tian Liu, Xiaofei Zhang, Andrew P Carter, Xiaoli Xiong, John A G Briggs
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-07-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010583&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010583&type=printable

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