Angiotensin-Converting Enzyme Inhibition as a Potential Risk Factor for Periprosthetic Joint Infection Following Total Knee Arthroplasty

Angiotensin-Converting Enzyme Inhibition as a Potential Risk Factor for Periprosthetic Joint Infection Following Total Knee Arthroplasty

Background: Periprosthetic joint infection (PJI) following total knee arthroplasty (TKA) portends significant morbidity. In-vivo studies demonstrating angiotensin-converting enzyme inhibitors (ACEis) may have an immunosuppressive effect. This study leveraged a large national registry to test if prop...

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Bibliographic Details
Main Authors: Rishi Trikha, MD, Nicolas Cevallos, BS, Alan L. Zhang, MD, Sanjiv M. Narayan, MD, PhD, Christos Photopoulos, MD, Alexandra Stavrakis, MD, Nicholas M. Bernthal, MD
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Arthroplasty Today
Subjects:
Periprosthetic joint infection
Total knee arthroplasty
Angiotensin-converting enzyme inhibitors
Angiotensin receptor blockers
Online Access:http://www.sciencedirect.com/science/article/pii/S2352344125000287
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