CFAP410 has a bimodular architecture with a conserved surface patch on its N-terminal leucine-rich repeat motif for binding interaction partners

CFAP410 has a bimodular architecture with a conserved surface patch on its N-terminal leucine-rich repeat motif for binding interaction partners

Cilia and flagella associated protein 410 (CFAP410) is a protein localized at the basal body of cilia/flagella and plays essential roles in ciliogenesis. Multiple single amino acid mutations in CFAP410 have been identified in patients. However, the molecular mechanism for how the mutations cause the...

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Main Authors: Alexander Stadler, Heloisa B. Gabriel, Laryssa V. De Liz, Santiago Alonso-Gil, Xuan Deng, Robbie Crickley, Katharina Korbula, Barbora Mikolaskova, Sue Vaughan, Kaiyao Huang, Bojan Žagrović, Jack D. Sunter, Gang Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CFAP410
cilium
ciliopathies
flagellum
protein
structure
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1507470/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1507470/full

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