Generation of a Transgenic <i>Plasmodium cynomolgi</i> Parasite Expressing <i>Plasmodium vivax</i> Circumsporozoite Protein for Testing <i>P. vivax</i> CSP-Based Malaria Vaccines in Non-Human Primates

Generation of a Transgenic <i>Plasmodium cynomolgi</i> Parasite Expressing <i>Plasmodium vivax</i> Circumsporozoite Protein for Testing <i>P. vivax</i> CSP-Based Malaria Vaccines in Non-Human Primates

<b>Background/Objectives</b>: Malaria, caused by infection with <i>Plasmodium</i> parasites, exacts a heavy toll worldwide. There are two licensed vaccines for malaria as well as two monoclonal antibodies that have shown promising efficacy in field trials. The vaccines and mo...

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Bibliographic Details
Main Authors: Maya Aleshnick, Shreeya Hegde, Charlie Jennison, Sebastian A. Mikolajczak, Ashley M. Vaughan, Derek Haumpy, Thomas Martinson, Judith Straimer, Brandon K. Wilder
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Vaccines
Subjects:
<i>Plasmodium vivax</i>
<i>Plasmodium cynomolgi</i>
pre-erythrocytic malaria vaccines
circumsporozoite protein
hypnozoite
Online Access:https://www.mdpi.com/2076-393X/13/5/536
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