Addition of bedtime lafutidine inhibits nocturnal acid-breakthrough and improves sleep quality in gastroesophageal reflux disease patients on esomeprazole: a randomized controlled trial

Addition of bedtime lafutidine inhibits nocturnal acid-breakthrough and improves sleep quality in gastroesophageal reflux disease patients on esomeprazole: a randomized controlled trial

Abstract This study aims to evaluate the acid inhibition and clinical improvement of the addition of bedtime lafutidine to esomeprazole in comparison with esomeprazole only in Gastroesophageal reflux disease (GERD) patients with nocturnal symptoms. We conducted a single-center, observer-blinded, ran...

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Bibliographic Details
Main Authors: Dongke Wang, Ruohang He, Xiaohao Zhang, Chaofan Duan, Tao Bai, Junying Xu, Xuelian Xiang, Xiaohua Hou
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Gastroesophageal Reflux Disease
Intragastric pH
Nocturnal Acid-Breakthrough
Proton Pump Inhibitor
Histamine-2 Receptor Antagonist
Sleep quality
Online Access:https://doi.org/10.1038/s41598-025-06767-3
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https://doi.org/10.1038/s41598-025-06767-3

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