Gαi2- and Gαi3-deficient mice display opposite severity of myocardial ischemia reperfusion injury.

Gαi2- and Gαi3-deficient mice display opposite severity of myocardial ischemia reperfusion injury.

G-protein-coupled receptors (GPCRs) are the most abundant receptors in the heart and therefore are common targets for cardiovascular therapeutics. The activated GPCRs transduce their signals via heterotrimeric G-proteins. The four major families of G-proteins identified so far are specified through...

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Main Authors: David Köhler, Vasudharani Devanathan, Claudia Bernardo de Oliveira Franz, Therese Eldh, Ana Novakovic, Judith M Roth, Tiago Granja, Lutz Birnbaumer, Peter Rosenberger, Sandra Beer-Hammer, Bernd Nürnberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0098325
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https://doi.org/10.1371/journal.pone.0098325

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