Multi-omics analysis unveils a four-gene prognostic signature in esophageal squamous carcinoma and the therapeutic potential of PKP1

Multi-omics analysis unveils a four-gene prognostic signature in esophageal squamous carcinoma and the therapeutic potential of PKP1

Abstract Background Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies, characterized by high heterogeneity and poor outcomes. Effective classification for patient stratification and identifying reliable markers for prognosis prediction and treatment choice are crucial....

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Bibliographic Details
Main Authors: Xiuzhi Zhang, Zhi Wang, Yutong Zhao, Hua Ye, Tiandong Li, Han Wang, Guiying Sun, Feifei Liang, Liping Dai, Peng Wang, Xiaoli Liu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Cancer
Subjects:
Esophageal squamous cell carcinoma
scRNA-seq
Heterogeneity
PKP1
JUP
Gene effect
Online Access:https://doi.org/10.1186/s12885-025-14150-8
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https://doi.org/10.1186/s12885-025-14150-8

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