Investigation into the influence of mild hypothermia on regulating ferroptosis through the P53-SLC7A11/GPX4 signaling pathway in sepsis-induced acute lung injury

Investigation into the influence of mild hypothermia on regulating ferroptosis through the P53-SLC7A11/GPX4 signaling pathway in sepsis-induced acute lung injury

Abstract Background Sepsis-induced acute lung injury (S-ALI) significantly contributes to unfavorable clinical outcomes. Emerging evidence suggests a novel role for ferroptosis in the pathophysiology of ALI, though the precise mechanisms remain unclear. Mild hypothermia (32–34 °C) has been shown to...

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Bibliographic Details
Main Authors: Liujun Tao, Jie Xu, Liangyan Jiang, Juntao Hu, Zhanhong Tang
Format: Article
Language:English
Published: SpringerOpen 2025-01-01
Series:Intensive Care Medicine Experimental
Subjects:
Mild hypothermia
P53-SLC7A11/GPX4 signaling
Ferroptosis
Sepsis-induced acute lung injury
Online Access:https://doi.org/10.1186/s40635-025-00713-3
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https://doi.org/10.1186/s40635-025-00713-3

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