Synthesis, in vitro and in silico studies of a novel chrysin-ferrocene Schiff base with potent anticancer activity via G1 arrest, caspase-dependent apoptosis and inhibition of topoisomerase II

Synthesis, in vitro and in silico studies of a novel chrysin-ferrocene Schiff base with potent anticancer activity via G1 arrest, caspase-dependent apoptosis and inhibition of topoisomerase II

A novel chrysin-ferrocene Schiff base (CFSB) was synthesised as a potential anticancer agent. CFSB demonstrated high cytotoxicity against cancer cells with HepG2 (liver) being the most susceptible (IC50 = 3.11 µM). The compound was less toxic towards normal MRC5 cells and exhibited ∼5-fold selectivi...

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Bibliographic Details
Main Authors: Mohammed Khaled Bin Break, Siddique Akber Ansari, Ahmed A. Katamesh, Najah Albadari, Maali D. Alshammari, Hamad M. Alkahtani
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Cancer
chrysin-ferrocene
topoisomerase
tubulin
molecular dynamics
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2025.2501377
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https://www.tandfonline.com/doi/10.1080/14756366.2025.2501377

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