CD28 shapes T cell receptor signaling by regulating Lck dynamics and ZAP70 activation

CD28 shapes T cell receptor signaling by regulating Lck dynamics and ZAP70 activation

IntroductionT cell activation requires T cell receptor (TCR) engagement by its specific ligand. This interaction initiates a series of proximal events including tyrosine phosphorylation of the CD3 and TCRζ chains, recruitment, and activation of the protein tyrosine kinases Lck and ZAP70, followed by...

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Bibliographic Details
Main Authors: Kumarkrishna Raychaudhuri, Rohita Rangu, Alison Ma, Neriah Alvinez, Andy D. Tran, Sandeep Pallikkuth, Katherine M. McIntire, Joseph A. Garvey, Jason Yi, Lawrence E. Samelson
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
T cell signaling
CD28 co-stimulation
Lck
ZAP70
microcluster
and kinetic proof-reading
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1503018/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1503018/full

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