Efficient generation of germline chimeras in a non-rodent species using rabbit induced pluripotent stem cells

Efficient generation of germline chimeras in a non-rodent species using rabbit induced pluripotent stem cells

Abstract Pluripotent stem cells have long been used to produce knockout mice via germline chimera technology. However, aside from the rat, this approach has not been successfully applied to other mammals. Here, we demonstrate that rabbit induced pluripotent stem cells (iPSCs) can be reprogrammed usi...

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Main Authors: Hong-Thu Pham, Florence Perold, Yannicke Pijoff, Nathalie Doerflinger, Sylvie Rival-Gervier, Maëlle Givelet, Anaïs Moulin, Manon Ressaire, Emilie Da Silva Fernandes, Valeska Bidault, Luc Jouneau, Véronique Duranthon, Florence Wianny, Bertrand Pain, Ingrid Plotton, Thierry Joly, Marielle Afanassieff, Pierre Savatier, Nathalie Beaujean
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60314-2
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https://doi.org/10.1038/s41467-025-60314-2

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