First‐In‐Human Study of Safety, Tolerability, Efficacy, and Pharmacokinetics of CPNE7‐Derived Peptide (Selcopintide) for Dentin Hypersensitivity

First‐In‐Human Study of Safety, Tolerability, Efficacy, and Pharmacokinetics of CPNE7‐Derived Peptide (Selcopintide) for Dentin Hypersensitivity

ABSTRACT Dentin hypersensitivity is characterized by transient, sharp pain resulting from dentin exposure due to enamel or cementum loss. Current treatments, which primarily focus on superficial tubule occlusion or nerve desensitization, provide only temporary relief. Copine7 (CPNE7) induces odontob...

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Main Authors: Myung Jin Lee, Yoon Seon Lee, Joo‐Cheol Park, Hyun Chul Kim, So Hyun Park, Howard Lee, Won Jun Shon
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Clinical and Translational Science
Subjects:
clinical trials
efficacy
pharmacokinetics
safety
tolerance
Online Access:https://doi.org/10.1111/cts.70326
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https://doi.org/10.1111/cts.70326

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