Integrated lncRNA and mRNA analysis reveals the immune modulatory mechanisms of antimicrobial peptide BSN-37 in mouse peritoneal macrophages

Integrated lncRNA and mRNA analysis reveals the immune modulatory mechanisms of antimicrobial peptide BSN-37 in mouse peritoneal macrophages

Abstract Antimicrobial peptides (AMPs) possess vaccine adjuvant activity; however, their specific targets and molecular mechanisms remain incompletely understood, which hinders their clinical application. This study aimed to elucidate the key targets and pathways through which the antimicrobial pept...

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Main Authors: Huihui Zhang, Yanhe Lv, Jingjing Li, Bingze Jiao, Jiahui Fu, Xujie Zhao, Likun Cheng, Yilin Bai, Lei Wang, Yanwei Li, Bolin Hang, Xiaobing Wei, Mingcheng Liu, Zhanwei Teng, Meinan Chang, Chengshui Liao, Yueyu Bai, Xiaojing Xia, Ke Ding, Jianhe Hu
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Antimicrobial peptide
Adjuvants
Macrophages
Long non-coding RNA
Online Access:https://doi.org/10.1038/s41598-025-03969-7
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https://doi.org/10.1038/s41598-025-03969-7

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