Immune suppression by neutrophils in HIV-1 infection: role of PD-L1/PD-1 pathway.

HIV-1 infection is associated with a progressive loss of T cell functional capacity and reduced responsiveness to antigenic stimuli. The mechanisms underlying T cell dysfunction in HIV-1/AIDS are not completely understood. Multiple studies have shown that binding of program death ligand 1 (PD-L1) on...

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Bibliographic Details
Main Authors: Nathan L Bowers, E Scott Helton, Richard P H Huijbregts, Paul A Goepfert, Sonya L Heath, Zdenek Hel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1003993
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