Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide pathway
Summary: Nori is a component of the traditional Japanese diet. The Japanese have a low prevalence of obesity and cardiovascular disease worldwide, and components of nori may have disease-preventive effects. Here, we focused on porphyran, which is abundant in nori that is discarded due to discolorati...
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Elsevier
2025-06-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225008648 |
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| author | Yoko Yokoyama Yoko Takashina Jean-David Morel Tanon Taworntawat Naho Kitamura Utana Nagano Tatsuya Tanigaki Anna Nakamura Teruo Miyazaki Hiroki Taoka Adrienne Mottis Alessia Perino Atsushi Shinjo Norihiro Suzuki Setsuo Takekawa Shinji Fukuda Akira Honda Kenji Ishihara Makoto Arita Kazuo Tsubota Johan Auwerx Mitsuhiro Watanabe |
| author_facet | Yoko Yokoyama Yoko Takashina Jean-David Morel Tanon Taworntawat Naho Kitamura Utana Nagano Tatsuya Tanigaki Anna Nakamura Teruo Miyazaki Hiroki Taoka Adrienne Mottis Alessia Perino Atsushi Shinjo Norihiro Suzuki Setsuo Takekawa Shinji Fukuda Akira Honda Kenji Ishihara Makoto Arita Kazuo Tsubota Johan Auwerx Mitsuhiro Watanabe |
| author_sort | Yoko Yokoyama |
| collection | DOAJ |
| description | Summary: Nori is a component of the traditional Japanese diet. The Japanese have a low prevalence of obesity and cardiovascular disease worldwide, and components of nori may have disease-preventive effects. Here, we focused on porphyran, which is abundant in nori that is discarded due to discoloration, and investigated the effects of nori-derived porphyran on gut microbiota, bile acid composition, and ceramide synthesis. Administration of porphyran to mice prevented obesity, diabetes, metabolic dysfunction-associated steatohepatitis (MASH), and hepatocellular carcinoma (HCC). This improvement correlates with a decrease in secondary bile acids, a decrease in intestinal farnesoid X receptor (FXR) signaling, and a marked decrease in blood ceramide. Porphyran, abundant in discolored nori, should be the subject of future translational research to prevent diseases with significant unmet medical needs and improve global environmental sustainability. |
| format | Article |
| id | doaj-art-83301d27ddb247b7bd850a5d8b2b3411 |
| institution | DOAJ |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-83301d27ddb247b7bd850a5d8b2b34112025-08-20T03:13:03ZengElsevieriScience2589-00422025-06-0128611260310.1016/j.isci.2025.112603Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide pathwayYoko Yokoyama0Yoko Takashina1Jean-David Morel2Tanon Taworntawat3Naho Kitamura4Utana Nagano5Tatsuya Tanigaki6Anna Nakamura7Teruo Miyazaki8Hiroki Taoka9Adrienne Mottis10Alessia Perino11Atsushi Shinjo12Norihiro Suzuki13Setsuo Takekawa14Shinji Fukuda15Akira Honda16Kenji Ishihara17Makoto Arita18Kazuo Tsubota19Johan Auwerx20Mitsuhiro Watanabe21Graduate School of Media and Governance, Keio University, 5322, Endo, Fujisawa, Kanagawa 252-0882, Japan; Health Science Laboratory, Keio Research Institute at SFC, Keio University, 5322, Endo, Fujisawa, Kanagawa 252-0882, Japan; Health Science Lab Laboratories, Shonan Keiiku Hospital, 4360 Endo, Fujisawa, Kanagawa 252-0816, Japan; Corresponding authorHealth Science Laboratory, Keio Research Institute at SFC, Keio University, 5322, Endo, Fujisawa, Kanagawa 252-0882, JapanLaboratory of Integrative Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, SwitzerlandGraduate School of Media and Governance, Keio University, 5322, Endo, Fujisawa, Kanagawa 252-0882, Japan; Health Science Laboratory, Keio Research Institute at SFC, Keio University, 5322, Endo, Fujisawa, Kanagawa 252-0882, JapanGraduate School of Media and Governance, Keio University, 5322, Endo, Fujisawa, Kanagawa 252-0882, Japan; Health Science Laboratory, Keio Research Institute at SFC, Keio University, 5322, Endo, Fujisawa, Kanagawa 252-0882, JapanHealth Science Laboratory, Keio Research Institute at SFC, Keio University, 5322, Endo, Fujisawa, Kanagawa 252-0882, JapanHealth Science Laboratory, Keio Research Institute at SFC, Keio University, 5322, Endo, Fujisawa, Kanagawa 252-0882, JapanHealth Science Laboratory, Keio Research Institute at SFC, Keio University, 5322, Endo, Fujisawa, Kanagawa 252-0882, JapanJoint Research Center, Tokyo Medical University Ibaraki Medical Center, Ibaraki 300-0395, JapanHealth Science Laboratory, Keio Research Institute at SFC, Keio University, 5322, Endo, Fujisawa, Kanagawa 252-0882, JapanLaboratory of Integrative Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, SwitzerlandLaboratory of Metabolic Signaling, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, SwitzerlandGraduate School of Media and Governance, Keio University, 5322, Endo, Fujisawa, Kanagawa 252-0882, Japan; Health Science Laboratory, Keio Research Institute at SFC, Keio University, 5322, Endo, Fujisawa, Kanagawa 252-0882, JapanHealth Science Lab Laboratories, Shonan Keiiku Hospital, 4360 Endo, Fujisawa, Kanagawa 252-0816, JapanHealth Science Lab Laboratories, Shonan Keiiku Hospital, 4360 Endo, Fujisawa, Kanagawa 252-0816, JapanGraduate School of Media and Governance, Keio University, 5322, Endo, Fujisawa, Kanagawa 252-0882, Japan; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan; Gut Environmental Design Group, Kanagawa Institute of Industrial Science and Technology, Kawasaki, Kanagawa 210-0821, Japan; Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Laboratory for Regenerative Microbiology, Juntendo University Graduate School of Medicine, Hongo, Tokyo 113-8421, JapanJoint Research Center, Tokyo Medical University Ibaraki Medical Center, Ibaraki 300-0395, Japan; Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki 300-0395, JapanSeafood Safety and Technology Division, Fisheries Technology Institute, Japan Fisheries Research and Education Agency, Yokohama 236-8648 JapanRIKEN Center for Integrative Medical Sciences, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan; Division of Physiological Chemistry and Metabolism, Graduate School of Pharmaceutical Sciences, Keio University, Shibakoen, Minato-ku, Tokyo 105-0011, JapanHealth Science Laboratory, Keio Research Institute at SFC, Keio University, 5322, Endo, Fujisawa, Kanagawa 252-0882, Japan; Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Tsubota Laboratory, Inc., 35 Shinanomachi, CRIK E7, Shinjuku-ku, Tokyo 160-8582, JapanLaboratory of Integrative Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, SwitzerlandGraduate School of Media and Governance, Keio University, 5322, Endo, Fujisawa, Kanagawa 252-0882, Japan; Health Science Laboratory, Keio Research Institute at SFC, Keio University, 5322, Endo, Fujisawa, Kanagawa 252-0882, Japan; Health Science Lab Laboratories, Shonan Keiiku Hospital, 4360 Endo, Fujisawa, Kanagawa 252-0816, Japan; Faculty of Environment and Information Studies, Keio University, 5322, Endo, Fujisawa, Kanagawa 252-0882, Japan; Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Corresponding authorSummary: Nori is a component of the traditional Japanese diet. The Japanese have a low prevalence of obesity and cardiovascular disease worldwide, and components of nori may have disease-preventive effects. Here, we focused on porphyran, which is abundant in nori that is discarded due to discoloration, and investigated the effects of nori-derived porphyran on gut microbiota, bile acid composition, and ceramide synthesis. Administration of porphyran to mice prevented obesity, diabetes, metabolic dysfunction-associated steatohepatitis (MASH), and hepatocellular carcinoma (HCC). This improvement correlates with a decrease in secondary bile acids, a decrease in intestinal farnesoid X receptor (FXR) signaling, and a marked decrease in blood ceramide. Porphyran, abundant in discolored nori, should be the subject of future translational research to prevent diseases with significant unmet medical needs and improve global environmental sustainability.http://www.sciencedirect.com/science/article/pii/S2589004225008648Natural sciencesBiological sciencesPhysiologyEndocrinology |
| spellingShingle | Yoko Yokoyama Yoko Takashina Jean-David Morel Tanon Taworntawat Naho Kitamura Utana Nagano Tatsuya Tanigaki Anna Nakamura Teruo Miyazaki Hiroki Taoka Adrienne Mottis Alessia Perino Atsushi Shinjo Norihiro Suzuki Setsuo Takekawa Shinji Fukuda Akira Honda Kenji Ishihara Makoto Arita Kazuo Tsubota Johan Auwerx Mitsuhiro Watanabe Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide pathway iScience Natural sciences Biological sciences Physiology Endocrinology |
| title | Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide pathway |
| title_full | Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide pathway |
| title_fullStr | Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide pathway |
| title_full_unstemmed | Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide pathway |
| title_short | Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide pathway |
| title_sort | porphyran from discolored nori prevents metabolic syndrome through microbiota bile acid ceramide pathway |
| topic | Natural sciences Biological sciences Physiology Endocrinology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225008648 |
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