Radiation dosimetry and fasting-dependent hepatobiliary clearance of the VAChT-specific PET radioligand 18F-VAT in humans

Radiation dosimetry and fasting-dependent hepatobiliary clearance of the VAChT-specific PET radioligand 18F-VAT in humans

Abstract Background The vesicular acetylcholine transporter ligand (-)-(1-((2R,3R)-8-(2-[(18)F]fluoro-ethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)piperidin-4-yl)(4-fluorophenyl)-methanone (18F -VAT) enables positron emission tomography PET quantification of cholinergic dysfunction in neurolo...

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Bibliographic Details
Main Authors: Scott A. Norris, Noah L. Goldman, Mahdjoub Hamdi, Stephen M. Moerlein, Richard Laforest, Morvarid Karimi, Joel S. Perlmutter, Zhude Tu
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:EJNMMI Research
Subjects:
PET
VAChT
Radiation dosimetry
Vesicular acetylcholine transporter
Online Access:https://doi.org/10.1186/s13550-025-01273-z
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https://doi.org/10.1186/s13550-025-01273-z

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