Independent association of a 17q21 variant with exacerbations in type 2–low adult asthma

Independent association of a 17q21 variant with exacerbations in type 2–low adult asthma

Background: The genetic factors contributing to exacerbations in type 2–low asthma are not well understood. Objective: We sought to clarify the association between variants in gasdermin B/orosomucoid-like 3 (GSDMB/ORMDL3) on 17q21 and exacerbations in type 2–low asthma. Methods: This follow-up study...

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Main Authors: Yumi Ishiyama, MD, Hisako Matsumoto, MD, PhD, Hironobu Sunadome, MD, PhD, Yuji Tohda, MD, PhD, Takahiko Horiguchi, MD, PhD, Hideo Kita, MD, PhD, Kazunobu Kuwabara, MD, PhD, Keisuke Tomii, MD, PhD, Kojiro Otsuka, MD, PhD, Masaki Fujimura, MD, PhD, Noriyuki Ohkura, MD, PhD, Katsuyuki Tomita, MD, PhD, Akihito Yokoyama, MD, PhD, Hiroshi Ohnishi, MD, PhD, Yasutaka Nakano, MD, PhD, Tetsuya Oguma, MD, PhD, Soichiro Hozawa, MD, PhD, Yoshihiro Kanemitsu, MD, PhD, Tadao Nagasaki, MD, PhD, Isao Ito, MD, PhD, Tsuyoshi Oguma, MD, PhD, Hideki Inoue, MD, PhD, Tomoko Tajiri, MD, PhD, Toshiyuki Iwata, MD, PhD, Junya Ono, BS, Shoichiro Ohta, MD, PhD, Tomomitsu Hirota, DOS, PhD, Mayumi Tamari, MD, PhD, Akio Niimi, MD, PhD, Kenji Izuhara, MD, PhD, Michiaki Mishima, MD, PhD, Toyohiro Hirai, MD, PhD
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Journal of Allergy and Clinical Immunology: Global
Subjects:
Type 2–low asthma
asthma exacerbation
17q21
GSDMB
ORMDL3
rs7216389
Online Access:http://www.sciencedirect.com/science/article/pii/S2772829325001122
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