Elevated TIM3 expression on bone marrow T cells drives immune dysfunction in early relapsed blood cancer after allogeneic hematopoietic stem cell transplantation

Elevated TIM3 expression on bone marrow T cells drives immune dysfunction in early relapsed blood cancer after allogeneic hematopoietic stem cell transplantation

Abstract Relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the leading cause of treatment failure in patients with hematologic malignancies. To better understand the mechanisms underlying early relapse (ER), we comprehensively explored the expression of inhibitory...

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Main Authors: Thi Thuy Duong Pham, Su-Young Choi, Jeong Suk Koh, Bu-Yeon Heo, Sang-Woo Lee, Myung-Won Lee, Wonhyoung Seo, Yunseon Jang, Jung-Hyun Park, Deog-Yeon Jo, Seungyeul Yoo, Jaeyul Kwon, Ik-Chan Song
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Experimental Hematology & Oncology
Subjects:
T cell immunoglobulin and mucin domain 3 (TIM3)
Inhibitor receptors
Allogeneic hematologic stem cell transplantation (HSCT)
Early relapse (ER)
Double negative t cells (DNTs)
Regulatory t cells (Treg)
Online Access:https://doi.org/10.1186/s40164-025-00697-6
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https://doi.org/10.1186/s40164-025-00697-6

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