Homocitrullination of lysine residues mediated by myeloid-derived suppressor cells in the tumor environment is a target for cancer immunotherapy

Homocitrullination of lysine residues mediated by myeloid-derived suppressor cells in the tumor environment is a target for cancer immunotherapy

Background Homocitrullination is the post-translational modification of lysine that is recognized by T cells.Methods This study identified homocitrullinated peptides from aldolase, enolase, cytokeratin and binding immunoglobulin protein and used human leukocyte antigen (HLA) transgenic mice to asses...

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Bibliographic Details
Main Authors: Wei Xue, Victoria A Brentville, Suha Atabani, Peter Symonds, Katherine W Cook, Poonam Vaghela, Lindy G Durrant, David Boocock, Clare Coveney, Amanda K Miles, Sabaria Shah, Daisy Weston
Format: Article
Language:English
Published: BMJ Publishing Group 2021-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/7/e001910.full
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https://jitc.bmj.com/content/9/7/e001910.full

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