Biomimetic nanocomplexes loading with evolocumab and curcumin for synergistic anti-atherosclerosis therapy in ApoE−/− mice

Biomimetic nanocomplexes loading with evolocumab and curcumin for synergistic anti-atherosclerosis therapy in ApoE−/− mice

Abstract Atherosclerosis (AS), a leading contributor to global cardiovascular mortality, is primarily driven by the dual pathological processes of chronic persistent inflammation and dysregulated lipid metabolism. Current clinical interventions are predominantly limited to single-target approaches (...

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Bibliographic Details
Main Authors: Yi Liu, Shengchao Ma, Feng Li, Hanshuang Ding, Qi Zhang, Feifei Yu, Huiping Zhang, Yinju Hao, Bin Liu, Yideng Jiang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Nanobiotechnology
Subjects:
Atherosclerosis
Inflammation
Lipid metabolism
Nanodelivery system
Evolocumab
Curcumin
Online Access:https://doi.org/10.1186/s12951-025-03444-5
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https://doi.org/10.1186/s12951-025-03444-5

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