Preparation of Carrier-Free Inhalable Dry Powder of Rivaroxaban Using Two-Step Milling for Lung-Targeted Delivery

Preparation of Carrier-Free Inhalable Dry Powder of Rivaroxaban Using Two-Step Milling for Lung-Targeted Delivery

<b>Background/Objectives</b>: This study aimed to develop a dry powder inhalation (DPI) formulation of rivaroxaban (RVX) using a combination of bead milling (BM) and jet milling (JM) to enhance lung-targeted delivery for the effective treatment of pulmonary embolism while minimizing syst...

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Bibliographic Details
Main Authors: Young-Jin Kim, Jaewoon Son, Chang-Soo Han, Chun-Woong Park
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceutics
Subjects:
rivaroxaban
dry powder inhaler
pulmonary embolism
bead milling
jet milling
leucine
Online Access:https://www.mdpi.com/1999-4923/17/5/634
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