Skeletal Muscle Mitochondrial and Autophagic Dysregulation Are Modifiable in Spinal Muscular Atrophy

Skeletal Muscle Mitochondrial and Autophagic Dysregulation Are Modifiable in Spinal Muscular Atrophy

ABSTRACT Background Spinal muscular atrophy (SMA) is a health‐ and life‐limiting neuromuscular disorder. Although varying degrees of mitochondrial abnormalities have been documented in SMA skeletal muscle, the influence of disease progression on pathways that govern organelle turnover and dynamics a...

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Main Authors: Andrew I. Mikhail, Sean Y. Ng, Donald Xhuti, Magda A. Lesinski, Jennifer Chhor, Marc‐Olivier Deguise, Yves De Repentigny, Joshua P. Nederveen, Rashmi Kothary, Mark A. Tarnopolsky, Vladimir Ljubicic
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
autophagy
biogenesis
dynamics
exercise
mitophagy
urolithin A
Online Access:https://doi.org/10.1002/jcsm.13701
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https://doi.org/10.1002/jcsm.13701

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