Multi-omics profiling of TGF-β isoforms and regulatory miRNAs in astrocytic tumors reveals TGF-β-3 as a prognostic biomarker

Multi-omics profiling of TGF-β isoforms and regulatory miRNAs in astrocytic tumors reveals TGF-β-3 as a prognostic biomarker

BackgroundAstrocytic tumors, particularly glioblastomas, are aggressive brain malignancies with poor prognosis. Transforming growth factor-beta (TGF-β) isoforms—TGF-β-1, TGF-β-2, and TGF-β-3—play critical roles in glioma progression, yet their isoform-specific expression patterns and regulatory mech...

Full description

Saved in:

Bibliographic Details
Main Authors:	Klaudia Skóra, Damian Strojny, Dawid Sobański, Rafał Staszkiewicz, Kamil Bryś, Paweł Gogol, Krzysztof Bereza, Michalina Masternak, Beniamin Oskar Grabarek
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Series:	Frontiers in Oncology
Subjects:	transforming growth factor beta 1-3 astrocytic tumors survival analysis micro RNA molecular marker
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1592685/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Modulation of Neurturin Expression by Lumbosacral Spinal Stenosis, Lifestyle Factors, and Glycemic Dysregulation
by: Małgorzata Sobańska, et al.
Published: (2025-05-01)

Lifestyle and Clinical Predictors of Glial Cell Line-Derived Neurotrophic Factor Expression in Lumbosacral Stenosis-Related Ligamentum Flavum Degeneration
by: Dawid Sobański, et al.
Published: (2025-06-01)

Assessment of the Concentration of Transforming Growth Factor Beta 1–3 in Degenerated Intervertebral Discs of the Lumbosacral Region of the Spine
by: Rafał Staszkiewicz, et al.
Published: (2024-11-01)

The Influence of Adalimumab and Cyclosporine A on the Expression Profile of the Genes Related to TGFβ Signaling Pathways in Keratinocyte Cells Treated with Lipopolysaccharide A
by: Iwona Adwent, et al.
Published: (2020-01-01)

An Exploration of the Raya Dunayevskaya Collection – Marxist-Humanism: A Half-Century of its World Development
by: Eugene Gogol
Published: (2020-04-01)

High immersion/escapism motivation makes gaming disorder risk less dependent of playtime among highly engaged male gamers
by: Patrycja Kiszka, et al.
Published: (2024-09-01)

Adequacy of Anesthesia Guidance for Combined General/Epidural Anesthesia in Patients Undergoing Open Abdominal Infrarenal Aortic Aneurysm Repair; Preliminary Report on Hemodynamic Stability and Pain Perception
by: Michał Jan Stasiowski, et al.
Published: (2024-11-01)

Marx’s Philosophy of Revolution in Permanence: Its Significance for Our Time
by: Franklin Dmitryev, et al.
Published: (2018-05-01)

Evaluation of TGF-β isoforms based on selected clinical parameters in asthmatic patients
by: Marcelina Koćwin, et al.
Published: (2024-04-01)

Impact of MiRNAs on Wnt-related gene activity in breast cancer
by: Tomasz Sirek, et al.
Published: (2025-05-01)

Evaluation of serum levels of all the transforming growth factor β (TGF-β 1-3) isoforms in asthmatic patients
by: Marcelina Koćwin, et al.
Published: (2024-04-01)

VR Realism Scale-Revalidation of contemporary VR headsets on a Polish sample.
by: Natalia Lipp, et al.
Published: (2021-01-01)

WCN25-3005 Do Transforming Growth Factor-β (TGF-β) Isoforms Predict Chronic Kidney Disease Progression?
by: Alfred Meremo, et al.
Published: (2025-02-01)

Regulation of TGF-β Signal Transduction
by: Bing Zhao, et al.
Published: (2014-01-01)

Differential expression of TGFβ isoforms in breast cancer highlights different roles during breast cancer progression
by: Mahmood Y Hachim, et al.
Published: (2018-01-01)

Utilizing UAV and orthophoto data with bathymetric LiDAR in google earth engine for coastal cliff degradation assessment
by: Paweł Tysiąc, et al.
Published: (2025-01-01)

Targeting TGFβR2‐mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer
by: Huocong Huang, et al.
Published: (2019-10-01)

Polychrome relief decoration in the Sanctuary of the Hathor Shrine: preliminary remarks
by: Paulina Staszkiewicz
Published: (2024-10-01)

Insight into the structure of antitubercular Callyaerins: conformational studies and synthesis of a unique dehydroamino acid, β-aminodehydroalanine
by: Karolina Banaś, et al.
Published: (2025-08-01)

Fibrosis in PCLS: comparing TGF-β and fibrotic cocktail
by: Carlos Machahua, et al.
Published: (2025-01-01)

TGF-β: elusive target in diabetic kidney disease
by: Priya Rani, et al.
Published: (2025-12-01)

Exogenous Heparan Sulfate Enhances the TGF-β3-Induced Chondrogenesis in Human Mesenchymal Stem Cells by Activating TGF-β/Smad Signaling
by: Juan Chen, et al.
Published: (2016-01-01)

Wzrost pobudzany eksportem czy eksport stymulowany wzrostem sektora rolnego
by: Jacek Strojny
Published: (2018-03-01)

Ocena międzynarodowej konkurencyjności gospodarki rolno-żywnościowej w oparciu o macierz atrakcyjności oraz pozycji rynkowej
by: Jacek Strojny
Published: (2010-05-01)

Linking expression and function of Drosophila type-I TGF-β receptor baboon isoforms: Multiple roles of BaboA isoform in shaping of the adult central nervous system
by: Gyunghee G. Lee, et al.
Published: (2025-01-01)

Activities supporting and activating people in the homelessness crisis during the SARS-CoV-2 pandemic
by: Iwona Staszkiewicz-Grabarczyk
Published: (2022-04-01)

Education during the COVID-19 pandemic in the light of legal acts
by: Iwona Staszkiewicz-Grabarczyk
Published: (2021-08-01)

(The invisible) image of homelessness
by: Iwona Staszkiewicz-Grabarczyk
Published: (2023-11-01)

Differential Influence of Inositol Hexaphosphate on the Expression of Genes Encoding TGF-β Isoforms and Their Receptors in Intestinal Epithelial Cells Stimulated with Proinflammatory Agents
by: Małgorzata Kapral, et al.
Published: (2013-01-01)

Evaluating the Efficacy of Pre-Emptive Peribulbar Blocks with Different Local Anesthetics or Paracetamol Using the Adequacy of Anesthesia Guidance for Vitreoretinal Surgeries: A Preliminary Report
by: Michał Jan Stasiowski, et al.
Published: (2024-10-01)

TGF-β inhibitors: the future for prevention and treatment of liver fibrosis?
by: Weili Wang, et al.
Published: (2025-06-01)

The role of TGF-β superfamily in endometriosis: a systematic review
by: Xinyi Xu, et al.
Published: (2025-08-01)

TGF-β3 Restrains Osteoclastic Resorption Through Autophagy
by: Hui Liao, et al.
Published: (2024-11-01)

Modeling TGF-β in early stages of cancer tissue dynamics.
by: Gianluca Ascolani, et al.
Published: (2014-01-01)

The role of the TGF-β1 signaling pathway in the process of amelogenesis
by: Xiaoxue Ma, et al.
Published: (2025-04-01)

Research Progress on Tumor Treatment Strategies Targeting TGF-β
by: Jian ZHANG, et al.
Published: (2025-01-01)

Ovarian steroids modulate mRNA expression of ECM associated genes and collagen deposition induced by TGF β1 in equine endometrium in vitro
by: Ana Amaral, et al.
Published: (2025-01-01)

Clinical observation of a patient with asthenic syndrome in the post-COVID-19 period
by: V. A. Sergeeva, et al.
Published: (2023-12-01)

TGFβ-specific T cells induced by a TGFβ-derived immune modulatory vaccine both directly and indirectly modulate the phenotype of tumor-associated macrophages and fibroblasts
by: Mads Hald Andersen, et al.
Published: (2024-02-01)

Gaming time and impulsivity as independent yet complementary predictors of gaming disorder risk
by: Paulina Daria Szyszka, et al.
Published: (2025-01-01)