Multi-omics profiling of TGF-β isoforms and regulatory miRNAs in astrocytic tumors reveals TGF-β-3 as a prognostic biomarker

Multi-omics profiling of TGF-β isoforms and regulatory miRNAs in astrocytic tumors reveals TGF-β-3 as a prognostic biomarker

BackgroundAstrocytic tumors, particularly glioblastomas, are aggressive brain malignancies with poor prognosis. Transforming growth factor-beta (TGF-β) isoforms—TGF-β-1, TGF-β-2, and TGF-β-3—play critical roles in glioma progression, yet their isoform-specific expression patterns and regulatory mech...

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Bibliographic Details
Main Authors: Klaudia Skóra, Damian Strojny, Dawid Sobański, Rafał Staszkiewicz, Kamil Bryś, Paweł Gogol, Krzysztof Bereza, Michalina Masternak, Beniamin Oskar Grabarek
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
Subjects:
transforming growth factor beta 1-3
astrocytic tumors
survival analysis
micro RNA
molecular marker
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1592685/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1592685/full

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