Molecular crosstalk in perivascular adipose tissue: mechanisms of inflammation, metabolic dysregulation, and therapeutic opportunities in cardiovascular disease

Molecular crosstalk in perivascular adipose tissue: mechanisms of inflammation, metabolic dysregulation, and therapeutic opportunities in cardiovascular disease

The escalating recognition of perivascular adipose tissue (PVAT) as a molecular nexus in cardiovascular disease (CVD) pathogenesis necessitates a comprehensive synthesis of its spatiotemporal dynamics and therapeutic potential. This review synthesizes PVAT's roles in vascular inflammation, meta...

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Main Authors: Shunhong Zhang, Jun Jiang, Yi Luo, Guangyue Liu, Saidi Hu, Siran Wan, Chenchen Luo, Hong Li, Nian Li, Jailson da Graça Espírito Santo Vasconcelos, Leonilde Lavres Ceita de Carvalho, Monazeri Lima Bragança da Costa, José Etchu Takounjou, Karem Maimite Das Neves, Luzimery dos Ramos da Conceição, Marinela da Costa Encarnação, Lin-Yong Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
perivascular adipose tissue
biomarkers
vascular inflammation
atherosclerosis
cardiovascular disease
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2025.1613900/full
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https://www.frontiersin.org/articles/10.3389/fcvm.2025.1613900/full

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